Evaluation of Interferon Alpha (IFN-α) in Women with Systemic Lupus Erythematosus in Iraq

Systemic Lupus Erythematosus (SLE) is a multifactorial chronic systemic autoimmune disease. It characterized by lack of immune tolerance to autoantigens such as nuclear antigens. The aim the study assess interferon-alpha (IFN-α) serum level in Iraqi patients with SLE and determine its potential relation different clinical laboratory parameters disease activity. 100 were all females mean age 31.3 ± 10 years (16-63years) duration 5.8 3.7years (1 month 15 years). average SLEDAI score ranged from 2 22 (8.53 ±3.42). Proteinuria, ESR, creatinine AST significantly higher (65% vs. 10% 0.62±0.11 0.70±0.14 mg/dl respectively) while PLT was lower (231.9±88.8 282.3±67.3 103/mL) (p< 0.001) among compared control. Serum levels IFN-α increased control, no significant difference has been observed (208.7±530.0 63.7±34.8 pg/ml) respectively (P=0.245). Interferon-alpha showed negative correlation Disease Activity Index (SLEDAI) active inactive groups. There variations across (p greater than 0.05). In conclusion, results suggest risk effect for female gender etiology SLE. could not be considered biomarker or have perpetuate No evidence any between manifestations investigation current except duration, which suggests them factor increasing level.